Psychedelic-Assisted Therapy

Psychedelic-Assisted Therapy (P.A.T.) is an emerging therapeutic approach that combines the use of psychedelic substances with psychotherapy to treat various mental health conditions.

Profound changes through P.A.T.

This innovative treatment method involves administering controlled doses of psychedelics, such as psilocybin, MDMA, or LSD, under the supervision of trained therapists in a clinical setting. The therapeutic process often includes preparatory sessions before the psychedelic experience, the monitored psychedelic session itself, and integration sessions afterward to help patients process and incorporate the insights gained.

Research has shown promising results for PAT in treating conditions like depression, anxiety, PTSD, and substance use disorders, demonstrating significant improvements where traditional therapies have been less effective.

The resurgence of interest in PAT is supported by rigorous clinical studies and growing evidence of its potential to provide transformative and lasting mental health benefits.

How P.A.T. is performed

Psychedelic-Assisted Therapy (PAT) is performed in a structured, multi-phase process designed to maximize therapeutic benefits and ensure patient safety. Here is an overview of how PAT is typically conducted:

Preparation Phase

Assessment for PAT

Screening and Assessment

Patients undergo thorough screening to assess their suitability for PAT, including medical history and mental health evaluation.

Preparation Sessions​

Patients meet with therapists to discuss their intentions, set goals, and build trust. They receive education about the psychedelic substance and what to expect during the session.

Psychedelic Session

Administration

The psychedelic substance (e.g., psilocybin, MDMA) is administered in a controlled, clinical environment. Dosages are carefully measured to ensure safety and efficacy.

Guided Experience

Patients are monitored and supported by therapists throughout the session, which can last several hours. The environment is designed to be comfortable, safe, and supportive, often including calming music.

PAT

Integration Phase

Integration Sessions PAT

Integration Sessions

Post-session therapy involves discussing the experience, processing emotions, and integrating insights gained during the psychedelic experience into everyday life. 

These sessions are crucial for translating the therapeutic gains into lasting behavioral changes.

What type of substances are used and why are they so effective in psychotherapy

Psychedelic-assisted therapy typically involves substances like psilocybin (from magic mushrooms), MDMA (ecstasy), LSD, and sometimes ketamine. These substances are used because they have profound effects on consciousness, perception, and cognition, which can facilitate therapeutic processes.

Here’s why they are effective in combination with psychotherapy:

Enhanced Neuroplasticity and Brain Connectivity

Psychedelics can increase neuroplasticity, which is the brain’s ability to reorganize and form new connections. This can help individuals break free from rigid patterns of thought and behavior, making psychotherapeutic insights and changes more accessible and lasting.​

Altered State of Consciousness

These substances induce altered states of consciousness characterized by enhanced introspection, emotional openness, and heightened awareness of thoughts and feelings. This state can facilitate deep introspection and exploration of underlying psychological issues.

Increased Emotional Release and Insight

Psychedelics often lead to emotional release and profound insights into one’s life and behavior. This can provide new perspectives on past experiences and traumas, allowing for emotional processing and healing.

Facilitation of Therapeutic Alliance

Under the guidance of trained therapists, the psychedelic experience can strengthen the therapeutic alliance by fostering trust, empathy, and a shared journey towards healing.

Reduction of Default Mode Network Activity

Psychedelics tend to decrease activity in the brain’s default mode network (DMN), which is associated with self-referential thoughts and the ego. This can reduce ego defenses and increase receptivity to new perspectives and therapeutic interventions.

Spiritual or Transpersonal Experiences

Many individuals report profound spiritual or transpersonal experiences during psychedelic sessions. These experiences can provide a sense of interconnectedness, meaning, and purpose, which can be therapeutic in the context of existential or spiritual crises.

Rapid Onset of Therapeutic Effects

Unlike traditional therapies that may take months to show significant results, psychedelics can induce rapid and profound therapeutic effects even after just a few sessions.

It’s important to note that psychedelic-assisted therapy is conducted in a controlled setting with trained therapists to maximize safety and therapeutic benefit. The combination of these substances with psychotherapy leverages their unique pharmacological properties to catalyze therapeutic processes and promote psychological healing.

What are the benefits psilocybin in micro- and macrodoses?

Psilocybin, the active compound in magic mushrooms, can be used in two different dosing strategies: microdosing and macrodosing. Here are the benefits associated with each:

Here are the benefits associated with each:

Microdosing

1. Enhanced Mood and Creativity: Microdosing psilocybin is often reported to enhance mood, increase creativity, and improve cognitive function without inducing hallucinations or significant alterations in perception.

2. Improved Focus and Energy: Users of microdoses often report increased focus, productivity, and energy levels. This can be beneficial for tasks that require sustained attention and mental clarity.

3. Potential for Anxiety and Depression Relief: Some individuals report alleviation of symptoms related to anxiety and depression with microdosing. It may help in regulating mood and reducing emotional reactivity.

4. Subtle Mindfulness and Emotional Awareness: Microdosing can enhance mindfulness and emotional awareness, making it easier to notice and work through underlying emotions and patterns in daily life.

5. Reduced Side Effects: Microdosing typically avoids the intense psychedelic effects associated with higher doses, thus minimizing the risk of adverse reactions or overwhelming experiences.

Macrodosing

1. Deep Psychological Insights: Macrodoses of psilocybin can induce profound alterations in consciousness, leading to deep insights into one’s psyche, emotional processing, and personal history. This can facilitate significant therapeutic breakthroughs.

2. Ego Dissolution and Transcendental Experiences: Higher doses can lead to experiences of ego dissolution, where the boundaries between self and other may dissolve, fostering a sense of interconnectedness and unity. This can have lasting positive effects on one’s worldview and sense of purpose.

3. Intensive Emotional Healing: Macrodosing can facilitate intense emotional release and healing by allowing individuals to confront and process unresolved trauma or difficult emotions in a supportive therapeutic setting.

4. Behavioral Changes and Habit Breaking: Higher doses of psilocybin may help individuals break free from entrenched behavior patterns, addictions, or negative thought cycles by providing a reset or new perspective on their life and choices.

5. Spiritual and Mystical Experiences: Some users report profound spiritual or mystical experiences under the influence of higher doses of psilocybin, which can lead to profound insights into existential questions and personal growth.

Both microdosing and macrodosing have their respective benefits depending on the desired outcomes and individual needs. Microdosing is often integrated into daily routines for ongoing support, while macrodosing is typically used in structured therapeutic sessions or retreat settings for deeper psychological exploration and healing. It’s crucial to approach both forms of dosing with caution, ideally under the guidance of a qualified healthcare provider or therapist experienced in psychedelic-assisted therapy.

1. “Psychedelic-Assisted Therapy: A Paradigm Shift in Psychiatric Treatment.” Psychiatry Research, 2021.

2. “The Safety and Efficacy of Psychedelic Therapy for Mental Health Conditions.” Journal of Psychopharmacology, 2020.

3. “Integration of Psychedelic Experiences in Psychotherapy.” Frontiers in Psychology, 2019.

Microdosing:

   – Anderson, T., & Petranker, R. (2020). Psychedelic Microdosing Benefits and Challenges: An Empirical Codebook. Harm Reduction Journal, 17(1), 1-9. [Read the study]

   – Prochazkova, L., et al. (2018). Exploring the effect of microdosing psychedelics on creativity in an open-label natural setting. Psychopharmacology, 235(12), 3401-3413. [Read the study]

   – Hutten, N. R., Mason, N. L., & Dolder, P. C. (2019). Microdosing psychedelics: Personality, mental health, and creativity differences in microdosers. Psychopharmacology, 236(2), 731-740. [Read the study]

Macrodosing:

   – Carhart-Harris, R. L., et al. (2016). Psilocybin with psychological support for treatment-resistant depression: an open-label feasibility study. The Lancet Psychiatry, 3(7), 619-627. [Read the study]

   – Griffiths, R. R., et al. (2016). Psilocybin produces substantial and sustained decreases in depression and anxiety in patients with life-threatening cancer: A randomized double-blind trial. Journal of Psychopharmacology, 30(12), 1181-1197. [Read the study]

   – Roseman, L., et al. (2019). Emotional breakthrough and psychedelics: Validation of the Emotional Breakthrough Inventory. Journal of Psychopharmacology, 33(9), 1076-1087. [Read the study]

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